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Cell Biochemistry Martinsried |
2. Goal: The cause for POEE/PCS/CLS development is unknown. It could result either from preoperative or from operative conditions. The goal of this investigation was to screen blood samples for various leukocyte CD antigens as well as for changes in cytokines, soluble adhesion molecules, complement components, histamine, neopterin, CRP, kreatinin, blood cell differentials as potential preoperative indicators for the occurrence of POEE.
3. Methods: The resulting database contained 59 preoperatively measured parameters for each of 9 POEE patients and 9 complication free patients (L4) Data were exported from Microsoft Excel format as dBase3 files, imported into the standardized multiparameter data classification program CLASSIF1) (L5) and subjected to iterative data pattern analysis.
4. Results: The retrospectively prospective classification (L4) shows that all (100%) CLS patients can be preoperatively identified from a pattern of 10 of the 59 parameters. Increased age, weight, IL-10, soluble ICAM-1, E-selectin, PECAM, serum and urine histamine, % and absolute granulocyte counts in combination with a decrease of C1-inhibitor concentration are preoperative indicators for postoperative POEE occurrence. The preoperative parameter changes in the risk patients are compatible with the existence of a latent preoperative infection.
4. Conclusion: The CLASSIF1 triple matrix analysis provides a preoperative risk indicator, a hypothesis how POEE/PCS/CLS may be generated and a means for therapy control (L1, L2, L3, L4) Provided the above hypothesis is correct, preoperative antibiotic treatment and recontrol of the data pattern at several days interval should permit to follow the normalization of the above parameter pattern. In case the parameter pattern has normalized the POEE risk should be reduced.
Literature References:
L1
J Bocsi, J Hambsch, P Osmancik, P Schneider,G Valet, A Tarnok
(2002) Preoperative prediction of pediatric patients with effusions
and edema following cardiopulmonary bypass surgery by serological and
routine laboratory data. Critical Care
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