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CLASSIF1 Classification |
- Displayed are the triple matrix patterns of ten sequential
5-year survivor and 5-year non survivor AML patients from
the classification the
in fig.2A.
- The disease classification masks
fig.3
for the reference group of patients ( > 5-year,
> 2 year survival) typically contains a sequence of (0)
characters because the majority of the parameter values is
located between the two percentile thresholds
10-90%, 15-85%, 20-80%, 25-75%, 30-70% of the value distributions.
As an example, 80% of the values are (0) for the percentile pair 10-90%,
10% are below (-) the lower percentile and 10% above (+)
the upper percentile.
- Unknown patients are classified according to the highest positional
coincidence of their patient classification mask with any of
the disease classification masks.
- The degree of coincidence between the patient mask
and the best fitting disease mask is expressed by
the disease coincidence factor. The coincidence factor
is 1.00 for patients #100073 and #080055 with four triple matrix
characters (0) and three characters (-) (arrows <= )
despite the fact that not all triple matrix characters are (0).
The reason for this is that triple matrix characters in
those parts of the reference value distribution curves which
are not occupied by the triple matrix characters of
the 5-year nonsurvivor disease mask count as positional
coincidences for the 5-year survivor disease mask.
With the 5-year nonsurvivor disease mask being: ++++++
the characters 0000000 and ------- belong to the 5-year survivor
disease mask.
- Nineteen patients are correctly classified while the one
patients #300040 is misclassified
- The patient disease masks labelled a) and b) are
repetitive. The systematic analysis of disease masks
may permit to define leukemia subgroups characterized by certain
preferential molecular CD expression patterns.
© 2024 G.Valet |